Colon cancer screening is becoming more popular as of late. We see home testing kits available and visits to the primary care doctor usually comes with the offer to do a colonoscopy. Why all the concern over intestinal health and cancer in this area?
An emerging health concern seen here in the United States as there’s a dramatic increase in colorectal cancer in younger patients. By 2030, it’s been projected that colorectal cancers will increase by 90%-125% in 20 to 34 year-olds and by 28% to 46% in 35 to 49 year-olds.
Because of this increase, the American Cancer Society has changed its recommendation to begin screening everybody earlier, by the age of 45 now.
The increase in occurrence of obesity and diabetes rates are often cited as cause for this increase in colorectal cancer. However, a recent study suggests that high-fructose corn syrup plays a major part by enhancing intestinal tumor growth.
Glucose is transported by intestinal epithelial cells in a very active manner by sodium-coupled glucose transporters. The fructose pathway, on the other hand, is mediated by a passive transporter. As little as 5 g of fructose can overwhelm this passive transporter. Rather than being absorbed, the fructose instead gets delivered to the colon.
High-fructose corn syrup can be found in almost all of the sweetened, pasteurized, and processed foods we consume. It is cheaper and sweeter than cane sugar, which is why it is a part of so many of these foods. High-fructose corn syrup has also been implicated in the growing epidemic of obesity, diabetes, and metabolic syndrome. Because of this connection, some states have placed restrictions on the sale of items containing high-fructose corn syrup. How they accomplish this is beyond me. They put limits on the number of large-volume sodas which can be purchased at any one time.
In the latest study, researchers used a bioengineered gene which would predispose mice to develop colon cancer then gave these mice what would be the equivalent of fructose consumed in one soda a day in a human, and what was observed was an increase in polyps which developed quickly into advanced high grade dysplastic lesions (cancer).
By using carbon labeling, researchers found increased uptake of fructose within the intestinal tumors themselves. High-fructose corn syrup accelerated the process of tumor growth and the transformation to a cancer. Intestinal growth generated by specific fatty acids created by the fructose leads to membrane stabilization, energy storage, and intestinal growth of these lesions. The synthesis of these fatty acids was very apparent as it relates to the high-fructose corn syrup model. It suggests that tumors rewire their metabolic pathways in favor of fatty acid synthesis after being exposed to high-fructose corn syrup.
The bulk of evidence showing correlation between high fructose corn syrup and the increase of inflammatory response should be enough to cause caution in consuming any food or drink containing it. Reading labels becomes of vital importance to your continued good health.
There’s tremendous correlation with high-fructose corn syrup driving cytokine upregulation. These cytokines are the foundation of pain and inflammation. There’s an abundance of data on this, particularly concerning inflammatory pathways in nonalcoholic fatty liver disease, steatohepatitis, and cell death in the liver. There’s similar work relating to cardiovascular disease and the development of things like atherosclerosis, atherosclerotic plaques, plaque rupture, and plaque thrombosis.
Although much of the data obtained on the effects of high fructose corn syrup have been obtained from mouse studies, it would be wisdom for anyone who’s had a polyp removed from their colon to completely eliminate corn syrup from their diet. If the effects of corn syrup contained in only one soda has the potential of instigating colorectal cancer, that soda needs to be a thing of the past.
Besides the detrimental effect of the fructose, most corn products, unless emphatically stated are from genetically modified sources. It’s hard to completely isolate yourself from this substance as it’s being used in a huge amount of foods due to it’s low cost and intense sweetness.
I’m not against foods that taste good, but we can be more selective in how we shop and what we decide to put in our bodies. If everyone boycotted foods with high fructose corn syrup, we would see more foods on the market which have switched to healthier choices. I occasionally indulge in a small amount of ice cream. I had to hunt to find one which has sought out a much safer alternative. Currently I have some Tillamook ice cream in the freezer. It should last me six months.
An emerging health concern seen here in the United States as there’s a dramatic increase in colorectal cancer in younger patients. By 2030, it’s been projected that colorectal cancers will increase by 90%-125% in 20 to 34 year-olds and by 28% to 46% in 35 to 49 year-olds.
Because of this increase, the American Cancer Society has changed its recommendation to begin screening everybody earlier, by the age of 45 now.
The increase in occurrence of obesity and diabetes rates are often cited as cause for this increase in colorectal cancer. However, a recent study suggests that high-fructose corn syrup plays a major part by enhancing intestinal tumor growth.
Glucose is transported by intestinal epithelial cells in a very active manner by sodium-coupled glucose transporters. The fructose pathway, on the other hand, is mediated by a passive transporter. As little as 5 g of fructose can overwhelm this passive transporter. Rather than being absorbed, the fructose instead gets delivered to the colon.
High-fructose corn syrup can be found in almost all of the sweetened, pasteurized, and processed foods we consume. It is cheaper and sweeter than cane sugar, which is why it is a part of so many of these foods. High-fructose corn syrup has also been implicated in the growing epidemic of obesity, diabetes, and metabolic syndrome. Because of this connection, some states have placed restrictions on the sale of items containing high-fructose corn syrup. How they accomplish this is beyond me. They put limits on the number of large-volume sodas which can be purchased at any one time.
In the latest study, researchers used a bioengineered gene which would predispose mice to develop colon cancer then gave these mice what would be the equivalent of fructose consumed in one soda a day in a human, and what was observed was an increase in polyps which developed quickly into advanced high grade dysplastic lesions (cancer).
By using carbon labeling, researchers found increased uptake of fructose within the intestinal tumors themselves. High-fructose corn syrup accelerated the process of tumor growth and the transformation to a cancer. Intestinal growth generated by specific fatty acids created by the fructose leads to membrane stabilization, energy storage, and intestinal growth of these lesions. The synthesis of these fatty acids was very apparent as it relates to the high-fructose corn syrup model. It suggests that tumors rewire their metabolic pathways in favor of fatty acid synthesis after being exposed to high-fructose corn syrup.
The bulk of evidence showing correlation between high fructose corn syrup and the increase of inflammatory response should be enough to cause caution in consuming any food or drink containing it. Reading labels becomes of vital importance to your continued good health.
There’s tremendous correlation with high-fructose corn syrup driving cytokine upregulation. These cytokines are the foundation of pain and inflammation. There’s an abundance of data on this, particularly concerning inflammatory pathways in nonalcoholic fatty liver disease, steatohepatitis, and cell death in the liver. There’s similar work relating to cardiovascular disease and the development of things like atherosclerosis, atherosclerotic plaques, plaque rupture, and plaque thrombosis.
Although much of the data obtained on the effects of high fructose corn syrup have been obtained from mouse studies, it would be wisdom for anyone who’s had a polyp removed from their colon to completely eliminate corn syrup from their diet. If the effects of corn syrup contained in only one soda has the potential of instigating colorectal cancer, that soda needs to be a thing of the past.
Besides the detrimental effect of the fructose, most corn products, unless emphatically stated are from genetically modified sources. It’s hard to completely isolate yourself from this substance as it’s being used in a huge amount of foods due to it’s low cost and intense sweetness.
I’m not against foods that taste good, but we can be more selective in how we shop and what we decide to put in our bodies. If everyone boycotted foods with high fructose corn syrup, we would see more foods on the market which have switched to healthier choices. I occasionally indulge in a small amount of ice cream. I had to hunt to find one which has sought out a much safer alternative. Currently I have some Tillamook ice cream in the freezer. It should last me six months.
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